November 4, 2026 · Google CloudFeature
AlphaGenome adds unified gRPC and HTTP streaming, keeps alphagenome-003
AlphaGenome gRPC and unified HTTP serving support
AlphaGenome (alphagenome-004) now supports unified HTTP/2 gRPC streaming and
chunked binary protobuf HTTP streaming on Gemini Enterprise Agent Platform:
- Streams compressed binary tensor chunks directly over gRPC on shared
endpoints (
PredictionService.StreamDirectRawPredicton port8081) and chunked binary protobuf payloads (proto_b64) over HTTP on dedicated endpoints (streamRawPredicton port8080) across all sevenDnaModelServicemethods (predict_sequence,predict_interval,predict_variant,score_variant,score_interval,score_ism_variants, andoutput_metadata) and 11 genomic modalities, reducing latency for 1 MB track predictions. - Supports concurrent multi-variant evaluation for in silico saturation
mutagenesis (
score_ism_variants) without HTTP gateway timeouts. - Supports model fold selection (
ALL_FOLDS,FOLD_0,FOLD_1,FOLD_2, andFOLD_3) across both gRPC and HTTP clients through the unifiedalphagenome_cloud_sdkPython SDK. - Retains
alphagenome-003in Model Garden for backward compatibility with existing legacy HTTP deployments.
For more information, see the AlphaGenome documentation.
Text from the Google Cloud release notes, licensed under CC BY 4.0. Source: Google Cloud release notes.
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